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Thursday, July 30, 2020 | History

2 edition of Enzymes of the intervertebral disc. found in the catalog.

Enzymes of the intervertebral disc.

Gordon Malcolm Herbert Colville

Enzymes of the intervertebral disc.

by Gordon Malcolm Herbert Colville

  • 32 Want to read
  • 8 Currently reading

Published by University of Manchester in Manchester .
Written in English


Edition Notes

Thesis (M.Sc.),- University of Manchester, Faculty of Medicine.

ContributionsUniversity of Manchester. Faculty of Medicine.
The Physical Object
Pagination245p.
Number of Pages245
ID Numbers
Open LibraryOL16576379M

  Intervertebral disc (IVD) degeneration remains a clinically important condition for which treatment is costly and relatively ineffective. The molecular basis of degenerative disc disease has been an intense focus of research recently, which has greatly increased our understanding of the biology underlying this process. Regenerative medicine is considered an attractive prospect for the treatment of intervertebral disc (IVD) degeneration. To assess the efficacy of the regenerative approach, animal models of IVD degeneration are needed. Among these animal models, chemonucleolysis based on the enzymatic degradation of the Nucleus Pulposus (NP) is often used, but this technique remains far from the natural.

Objective: To investigate the effects of menopause on redox balance in the intervertebral disc and to examine whether oxidative stress and autophagy were associated with disc degeneration in menopause rats. Methods: Thirty female Sprague-Dawley rats were randomly divided into three groups (sham, ovariectomized with vehicle, and ovariectomized with estrogen).   The lumbar intervertebral disc is known to be the largest avascular organ in the human body and the main path of nutrition or oxygen supply is passive diffusion via the endplates, resulting in poor nutrition and low oxygen tension, especially near the center of the disc (Grunhagen et al., ).

Explore the latest full-text research PDFs, articles, conference papers, preprints and more on INTERVERTEBRAL DISK. Find methods information, sources, references or conduct a . Alkalinize or Die. Portal Books California. 6 Markoff KL, Morris JM: The structural components of the intervertebral disc. J Bone and Joint Surgery ; 7 Saulter F, Oglive-Harris D: Healing in inter-articular fractures and continuous passive motion


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Enzymes of the intervertebral disc by Gordon Malcolm Herbert Colville Download PDF EPUB FB2

Longitudinal Comparison of Enzyme- and Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression Enzymes of the intervertebral disc.

book Disc Degeneration: A Rabbit Study Marion Fusellier, 1, 2 Pauline Colombier, 1, 3 Julie Lesoeur, 1, 3 Samy Youl, 1 Stéphane Madec, 1, 2 Olivier Gauthier, 1, 4 Olivier Hamel, 1 Cited by: 6. The method for treating intervertebral disc displacement in mammals which comprises injecting into the intervertebral disc space effective amounts of a pharmacologically suitable solution of the enzyme chondroitinase to bring about the selective chemonucleolysis of the nucleus by: enzyme dissolution of the nucleus pulposus in humans jama.

jan 11; doi: /jamaCited by: Objective. To investigate the effects of menopause on redox balance in the intervertebral disc and to examine whether oxidative stress and autophagy were associated with disc degeneration in menopause rats. Methods. Thirty female Sprague-Dawley rats were randomly divided into three groups (sham, ovariectomized with vehicle, and ovariectomized with estrogen).Cited by: 3.

Intervertebral disc degeneration is implicated as a leading cause of low back pain. Persistent, local inflammation within the disc nucleus pulposus (NP) and annulus fibrosus (AF) is an important mediator of disc degeneration and negatively impacts the performance of therapeutic stem by: 1.

There is some evidence that disc degeneration of cigarette smokers is of more severe degree than that of non-smokers. Cigarette-smoking increases serum proteolytic activity by releasing proteolytic enzymes from neutrophils in alveolar capillaries, and by inhibiting the activity of alphaantiprotease, the most potent protease inhibitor.

The depletion of chondroitin sulfates (CSs) within the intervertebral disc (IVD) during degenerative disc disease (DDD) results in a decrease in tissue hydration, a loss of. Intervertebral disks are the “cushions” in the space between spinal vertebrae.

These disks are subject to a number of degenerative conditions and forces that predispose them to bulge or rupture over time. This rupture leads to damage to the spinal cord. Intervertebral disk disease (IVDD) is the most common cause of spinal cord injury in dogs.

The regulation and elevation in expression of the catabolic matrix metalloproteinases (MMPs) is of high importance in the human intervertebral disc since upregulation of these matrix-degrading enzymes results in matrix destruction associated with disc degeneration. MMP28 (epilysin) is a newly discovered MMP believed to play a role in matrix composition and turnover in skin.

Introduction. Low back pain (LBP) has become a common disease in modern society and intervertebral disc degeneration (IVDD) is the main factor [].IVDD refers to the physiological and pathological process of natural aging and degradation of intervertebral disc [].It is a series of pathologic foundation of spinal degenerative diseases such as intervertebral disc herniation, spinal canal.

Results. Exposure of mice to 4 or 8 weeks of WBV did not alter total body composition or induce significant changes in vertebral bone density. On the other hand, WBV-induced intervertebral disc (IVD) degeneration, associated with decreased disc height and degenerative changes in the annulus fibrosus (AF) that did not recover within 4 weeks after cessation of WBV.

Canine intervertebral disc problems can be debilitating, often lead to forms of paralysis. Antioxidant enzymes can play a key role in the recovery process. 0 Items () There is biochemical evidence that the protein core of disc aggrecan is broken down by both aggrecanase and matrix metalloproteinases (MMPs) in human intervertebral disc (Strolovics et al.

We have studied the activity and location of these groups of enzymes in intervertebral discs of varying degrees of degeneration using the monoclonal. A must-have reference for optimizing the care of patients with lumbar intervertebral disc disorders Written by leading authorities in the field of spine care, this book is a comprehensive reference for the latest techniques for managing intervertebral disc disorders affecting the lumbar spine.

Divided into four main sections, the book opens with a review of fundamental basic science concepts. Results. Candidate gene linkage and association studies involving the functional components of the intervertebral disc, including collagen I, collagen IX, collagen XI, aggrecan, extracellular matrix-degrading enzymes, inflammatory cytokines (IL-1, IL-6, and TNFα), Fas/FasL and vitamin D receptors, have had promising results.

Adams MA, Hutton WC. Prolapsed intervertebral disc. A hyperflexion injury Volvo Award in Basic Science. Spine (Phila Pa ). May-Jun;7(3) Vo NV, Hartman RA, Yurube T, Jacobs LJ, Sowa GA, Kang JD.

Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. Introduction. Low back pain (LBP) is a common clinical problem that has a significant impact on today’s aging population.

While the etiology of back pain is multi-factorial, it has been associated with intervertebral disc (IVD) degeneration (1, 2).It has been suggested that the degenerative process begins in the nucleus pulposus (NP) of the IVD and is associated with progressive loss of.

This chapter discusses various enzymes and enzyme inhibitors. The nucleus pulposus of the intervertebral disk consists of a mucopolysaccharide gel in a collagen matrix. Chemical lysis of the nucleus pulposus of a herniated disk can be achieved by means of chymopapain, which breaks down the mucopolysaccharide–protein complexes.

Search the world's most comprehensive index of full-text books. My library. Introduction. Low back pain (LBP), one of the most common musculoskeletal complaints, has become a serious health and socioeconomic problem affecting modern society (1,2).Among numerous pain generators in the lumbar spine, intervertebral disc (IVD) degeneration is considered to be the most important contributor to LBP (3,4).IVD degeneration results from the excessive.

Written by leading authorities in the field of spine care, this book is a comprehensive reference for the latest techniques for managing intervertebral disc disorders affecting the lumbar spine. Divided into four main sections, the book opens with a review of fundamental basic science concepts, including epidemiology, anatomy, pathophysiology, biology, biomechanics, and mechanisms of pain.

Advances in Intervertebral Disc Disease in Dogs and Cats defines our present knowledge of this common clinical problem, compiling information related to the canine and feline intervertebral disc into a single resource. As a comprehensive, focused work, the book is an authoritative reference for understanding and treating disc disease, providing a sound scientific and Reviews: 3.

The definitive guide to intervertebral disk diseases. The new edition of this book provides the current information on the diagnostic techniques and therapeutic approaches that will help clinicians optimize care for patients with intervertebral disk disease.

The book covers the full range of problems frequently encountered in the clinical.