3 edition of Influence of genotype-treatment interactions in studies of emotionality in mice found in the catalog.
Influence of genotype-treatment interactions in studies of emotionality in mice
Joanne Ellsworth Jumonville
Written in English
|LC Classifications||Microfilm 20773|
|The Physical Object|
|Pagination||vii, 171 l.|
|Number of Pages||171|
|LC Control Number||94895419|
As to human subjects, T-patterns have been utilized to study patterns of interaction in autism disorders , self-injurious behavior in psychiatric patients [16,17], social interactions in. Studies show that environmental colour can influence emotionality and task performance in humans, suggesting that cage colour could also affect emotionality and performance of mice in behavioural.
Emotionality and aggressive behavior in the mouse as a function of infantile experience. J. Genet. Psychol. See also PubMed. Lieberman, M.W. Early developmental stress and later behavior. Science See also PubMed. Lindzey, G. Emotionality and audiogenic seizure susceptibility in five inbred strains of mice. J. There are many emotions that influence motivation and, as we've seen, motivation itself can change our behavior. In this way, if we can change our emotions, we might be able to change our behavior.
Introduction. Genotype‐by‐environment interactions (GxEs) occur whenever the relative performance of different genotypes is dependent on the biotic and/or abiotic environment in which they are expressed (Lynch & Walsh, ).GxEs have been extensively studied for over half a century in an agricultural context to improve crop yields and the efficacy of selective breeding programmes (see. Robert Ader, Ph.D. () was a member of the faculty of the Dept. of Psychiatry at the University of Rochester School of Medicine for fifty-five years. A pioneer in the field of psychoneuroimmunology, Ader was internationally recognized for work establishing the influence of the brain on the.
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Influence of Genotype-Treatment Interactions on Studies of “Emotionality” in Mice, Ph.D. dissertation. Department of Psychology, University of Chicago, Chicago. Department of Psychology, University of Chicago, by: These results are similar to those of human psychological disorders, and suggest that deprivation of the mother–infant interaction during the late lactation period in mice and rats provides an interesting animal model to understand the neuromolecular basis of and psychopharmacological treatments for human psychological disorders related to Cited by: 2.
The focus of GxE interaction studies in animal models of schizophrenia has taken advantage of the genetic tools available in mice, comparing mutant and control animals after adverse environmental exposures such as immune activation, stress or drug administration (Kannan et al., ).Cited by: Mice ranging in age from juvenile to older adult can be tested in this paradigm.
As mentioned above, attention should be given to the background strain, housing arrangements, and genetic mutations designed to influence emotionality, as these may alter baseline levels of feeding by: Jumonville, J.
Influence of genotype-treatment interaction in studies of “emotionality” in mice. Ph.D. dissertation, University of Chicago. Google ScholarCited by: It was observed that the factors “genotype,” “treatment,” and “genotype × treatment” interaction effects were present in most of the behaviors studied, such as decreased neophobia, and improved the development of exploratory activity in the open field in NTg mice but had a weak effect on these variables in the 3xTg-AD mice model.
Although much fewer data exist on socialization for mice, there is some evidence that the quality and quantity of interactions with laboratory mice also affect their well-being. In 1 study, 3 groups of adult mice were subjected to 1 of 3 treatments every second day for 13 days: gentle handling (placed in the palm of a hand and stroked on the.
This book represents the first comprehensive analysis of the role genotype-by-environment interactions play in sexual selection and the potential implications that they have for the evolutionary process. The Editors have identified 13 topics that currently define the field and shed light on the impacts of these interactions on sexual selection.
Previous studies concerned with genotype-environment interaction in behavior are discussed from methodological and gene-action points of view. A number of methodological advances have been made recently. In particular, designs introducing environmental variables factorially into standard genetic designs are extremely powerful.
It is evident that all the methods appropriate to the analysis of. It was observed that the factors “genotype,” “treatment,” and “genotype × treatment” interaction effects were present in most of the behaviors studied, such as decreased neophobia, and improved the development of exploratory activity in the open field in NTg mice but had a weak effect on these variables in the 3xTg-AD mice model.
In another approach to gene-environment interactions, the field of epigenetics looks beyond the genotype itself and studies how the same genotype can be expressed in different ways. In other words, researchers study how the same genotype can lead to very different phenotypes.
ICR mice are the most popular strain of mice (Owen and Flint, ). In this study, we confirmed the neonatal ICR mice may be used a very effective animal model for human neonatal C. sakazakii. COVID campus closures: see options for getting or retaining Remote Access to subscribed content.
Maternal behavior can moderate the effect of genetic and neurobiological manipulations that are being developed in mice to study the etiology of psychopathology. The protocol described in this chapter can be applied to these studies to examine the interplay between genes and the environment.
Genotype-by-environment interaction (GEI) is a fundamental component in understanding complex trait variation. However, it remains challenging to identify genetic variants with GEI effects in humans largely because of the small effect sizes and the difficulty of monitoring environmental fluctuations.
Here, we demonstrate that GEI can be inferred from genetic variants associated with phenotypic. Jumonville nce of Genotype-Treatment Interactions in Studies of ‘Emotionality’ in Mice Ph.D. dissertation, University of Chicago, Chicago, IL () Google Scholar.
Our studies also did not investigate the role of early life stress and SERT in the modulation of adult emotionality.
All mice were reared under non-stressful conditions, thus the baseline behavioral performance in young adult mice (~2–4 months of age) was equated with “trait” behavior.
Although it is unlikely that a single injection of sertraline would induce a reduction in testosterone levels in male mice in our study, an SRI-sex hormone interaction may influence the normal noradrenergic function that is maintained by the higher testosterone levels in male Ar-/-mice.
Investigation of gene–environment interactions in humans and nonhuman primates, as well as gene inactivation studies in mice, have further advanced the identification of genes that are essential for the development and plasticity of brain systems related to depression.
The interaction between genotype and environment is recognized as an important source of experimental variation when complex traits are measured in the mouse, but the magnitude of that interaction has not often been measured. From a study of genetically heterogeneous mice, we report the heritability of 88 complex traits that include models of human disease (asthma, type 2.
Although few studies have attempted QTL mapping of behavioral traits in animals, Turri et al. () reported three localizations for ''emotionality'' in mice, chromosomes 1, 12, and Their.
Fig. 1 and Table 1, Table 2, Table 3 show the behavioral phenotype exhibited at 6 months of age in the different tests and the effects of PH on these behaviors.
Download: Download high-res image (KB) Download: Download full-size image Fig. -term effects of postnatal handling on exploratory behaviors in C57BL/6 × and 3xTg-AD mice at 6-months of age. Fig. 1A–C. Horizontal .Probably all heritable traits, including disease susceptibility, are affected by interactions between mutations in multiple genes.
We understand little, however, about how genes interact to produce phenotypes, and there is little power to detect interactions between genes in human population studies.
An alternative approach towards understanding how mutations combine to produce phenotypes is.